Title:
オリゴヌクレオチド類似体
Document Type and Number:
Japanese Patent JP4236812
Kind Code:
B2
Abstract:
The present invention relates to novel bicyclic and tricyclic nucleoside and nucleotide analogues as well as to oligonucleotides comprising such elements. The nucleotide analogues, LNAs ( L ocked Nucleoside A nalogues), are able to provide valuable improvements to oligonucleotides with respect to affinity and specificity towards complementary RNA and DNA oligomers. The novel type of LNA modified oligonucleotides, as well as the LNAs as such, are useful in a wide range of diagnostic applications as well as therapeutic applications. Among these can be mentioned antisense applications, PCR applications, strand displacement oligomers, as substrates for nucleic acid polymerases, as nucleotide based drugs, etc. The present invention also relates to such applications.
Inventors:
Wenger, Jesus Par
Nilsen, Paul
Nilsen, Paul
Application Number:
JP2000511775A
Publication Date:
March 11, 2009
Filing Date:
September 14, 1998
Export Citation:
Assignee:
EXIQON A/S
International Classes:
C07H19/06; A61K31/7042; C12N15/09; A61K31/7052; A61K31/7064; A61K31/7072; A61K31/7076; A61K31/7088; A61K31/712; A61K48/00; A61P31/12; A61P35/00; C07D491/08; C07D493/04; C07D493/08; C07F7/18; C07F9/6558; C07H19/04; C07H19/16; C07H21/00; C07H23/00; C12N15/11; C12Q1/68
Domestic Patent References:
| JP10304889A | ||||
| JP10195098A |
Other References:
The Sixteenth International Congress of Heterocyclic Chemistry,1997年 8月10日,要旨番号POI-101
Chem.Commun.,1997年 5月 7日,No.9,p.825-826
Chem.Commun.,1997年 5月 7日,No.9,p.825-826
Attorney, Agent or Firm:
Shintaro Nogawa