Title:
多形核細胞及び単核細胞の走化性の阻害剤としてのR-2-アリール-プロピオン酸のオメガ-アミノアルキルアミド
Document Type and Number:
Japanese Patent JP4267922
Kind Code:
B2
Abstract:
(R)-2-Arylpropionamide compounds of formula (I), pharmaceutical preparations of the compounds and a process for making the compounds are described. The 2-Arylpropionamides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonuclear leukocytes and monocytes at inflammatory sites. In particular, the invention relates to the R enantiomers of omega-aminoalkylamides of 2-aryl propionic acids, of formula (I), for use as inhibitors of chemotaxis of neutrophils and monocytes induced by the C5a fraction of complement and by other chemotactic proteins whose biological activity is associated with activation of a 7-TD receptor. Selected compounds of formula (I) are dual inhibitors of both the C5a-induced chemotaxis of neutrophils and monocytes and the IL-8-induced chemotaxis of polymorphonuclear leukocytes.
Inventors:
Alegretti, Marcelo
Riccardo, Bertini
Berdini, Valerio
Bizari, shinjia
Sesta, Maria Candida
Di-sioccio, bito
Caseli, Gianfranco
Corotta, Francesco
Gandolfi, Carmelo
Riccardo, Bertini
Berdini, Valerio
Bizari, shinjia
Sesta, Maria Candida
Di-sioccio, bito
Caseli, Gianfranco
Corotta, Francesco
Gandolfi, Carmelo
Application Number:
JP2002567891A
Publication Date:
May 27, 2009
Filing Date:
February 25, 2002
Export Citation:
Assignee:
Dompe Fa.le.Ma Sochieta per Azioni
International Classes:
C07C233/40; A61K31/165; C07D295/12; A61K31/198; A61K31/439; A61K31/445; A61K31/4453; A61K31/5375; A61K31/5377; A61P1/04; A61P9/10; A61P11/00; A61P13/12; A61P17/02; A61P17/06; A61P19/02; A61P19/04; A61P29/00; A61P37/06; A61P43/00; C07C231/02; C07C231/16; C07C233/44; C07C233/51; C07C235/34; C07C235/70; C07C237/22; C07C279/12; C07C281/16; C07D211/58; C07D233/24; C07D233/46; C07D295/13; C07D295/14; C07D451/04
Domestic Patent References:
| JP57042663A | ||||
| JP54090157A | ||||
| JP49018875A | ||||
| JP2002502874A | ||||
| JP2003527603A |
Foreign References:
| WO2001079189A1 |
Other References:
Indian Journal of Pharmaceutical Sciences,1998年,60(6),p.346-352
Indian Journal of Pharmaceutical Sciences,1999年,61(3),p.158-161
Journal of Drug Targeting,1995年,2(6),p.517-525
Indian Journal of Pharmaceutical Sciences,1999年,61(3),p.158-161
Journal of Drug Targeting,1995年,2(6),p.517-525
Attorney, Agent or Firm:
Kazuo Shamoto
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita