PURPOSE: An ophthalmic liquid solution, containing 2-(2-fluoro-4-biphenylyl)propionic acid and β-or γ-cyclodextrin or further a viscous agent, having greatly reduced irritant action, and stable for a long term without side effects.
CONSTITUTION: The titled solution containing (A) 2-(2-fluoro-4-biphenylyl)propionic acid of the formula or a salt thereof and (B) β-or γ-cyclodextrin at 1:(0.5W1.5) molar ratio or further a viscous agent. The concentration of the component (A) in the solution is 0.001W2W/V%, and the pH of the solution is adjusted with a buffer agent to 5.0W8.0. In preparing the solution, the components (A) and (B), or a clathrate compound thereof, or a clathrate compound of the components (A) with (B) is dissolved in a water medium. The resultant solution is capable of solubilizing the component (A) in a high concentration, and therefore the inhibitory action on intraocular prostaglandins (PGs) and the mydriatic effect are more remarkable to give the marked effect on surgical operations, etc.
IGARI TAKASHI
MATSUYAMA TAKASHI
TERAJIMA AKIO
GOTOU TAKAO
| JPS5622730A | 1981-03-03 | |||
| JPS5634618A | 1981-04-06 |