Title:
OPHTHALMOLOGIC IRRIGATION SOLUTIONS AND OPHTHALMOLOGIC IRRIGATION METHOD
Document Type and Number:
Japanese Patent JP2016014055
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide solutions for local ocular delivery of multiple active agents that act on a plurality of differing molecular targets in order to perioperatively inhibit inflammation, inhibit pain, effect mydriasis (dilation of the pupil), and/or decrease intraocular pressure.SOLUTION: The invention relates to perioperative irrigation solutions for use during ophthalmologic procedures in order to inhibit inflammation, inhibit pain, effect mydriasis, and/or decrease intraocular pressure during the procedures. Each solution contains at least first and second therapeutic agents in a liquid irrigation carrier. The first and second therapeutic agents are selected to act on a plurality of differing molecular targets, and selected from the physiologic functional classes of anti-inflammatory agents, analgesic agents, mydriatic agents and agents for decreasing intraocular pressure ("IOP reducing agents"). The second agent provides at least one physiologic function different than functions provided by the first agent. Each agent is included at a concentration of 100,000 nM or less.
Inventors:
DEMOPULOS GREGORY A
PALMER PAMELA PIERCE
HERZ JEFFREY M
PALMER PAMELA PIERCE
HERZ JEFFREY M
Application Number:
JP2015193350A
Publication Date:
January 28, 2016
Filing Date:
September 30, 2015
Export Citation:
Assignee:
OMEROS CORP
International Classes:
A61K45/06; A61K9/00; A61K9/08; A61K31/00; A61K31/137; A61K31/19; A61K31/192; A61K31/196; A61K31/381; A61K31/407; A61K31/4174; A61K31/485; A61K31/56; A61K31/573; A61K31/7004; A61K38/00; A61P27/04; A61F
Domestic Patent References:
| JPH09506620A | 1997-06-30 |
Other References:
土坂寿行: "ＩＯＬ移植における手術補助剤と薬剤の用い方", あたらしい眼科, vol. 4, no. 6, JPN6009045151, 30 June 1987 (1987-06-30), JP, pages 755 - 759, ISSN: 0003351204
島田宏之, 他.: "抗プロスタグランディン剤を加えた灌流液の水晶体計画的嚢外摘出術における散瞳維持効果", あたらしい眼科, vol. 4, no. 5, JPN6009045157, 30 May 1987 (1987-05-30), JP, pages 719 - 722, ISSN: 0003351205
HOWARD, V., ET AL.: "The Effect of Treatment with Topical Nonsteroidal Anti-inflammatory Drugs with and without Intraoper", OPHTHALMOLOGY, vol. 96, no. 5, JPN6009045152, May 1989 (1989-05-01), pages 585 - 588, ISSN: 0003351206
木下 渥: "水晶体嚢外摘出術におけるフェニレフリン潅流の散瞳維持効果", 日本眼科紀要, vol. 40, no. 8, JPN6009045153, 28 August 1989 (1989-08-28), JP, pages 1730 - 1733, ISSN: 0003351207
あたらしい眼科, vol. １９（１）, JPN6015011648, 30 January 2002 (2002-01-30), JP, pages 107 - 109, ISSN: 0003351208
日眼会誌, vol. ９６（１１）, JPN6015011653, 1992, JP, pages 1379 - 1386, ISSN: 0003351209
西出忠之, 他.: "強度近視白内障手術での０．２％リドカイン眼内灌流麻酔法", 臨床眼科, vol. 53, no. 5, JPN6009045155, 15 May 1999 (1999-05-15), JP, pages 921 - 922, ISSN: 0003351210
島田宏之, 他.: "抗プロスタグランディン剤を加えた灌流液の水晶体計画的嚢外摘出術における散瞳維持効果", あたらしい眼科, vol. 4, no. 5, JPN6009045157, 30 May 1987 (1987-05-30), JP, pages 719 - 722, ISSN: 0003351205
HOWARD, V., ET AL.: "The Effect of Treatment with Topical Nonsteroidal Anti-inflammatory Drugs with and without Intraoper", OPHTHALMOLOGY, vol. 96, no. 5, JPN6009045152, May 1989 (1989-05-01), pages 585 - 588, ISSN: 0003351206
木下 渥: "水晶体嚢外摘出術におけるフェニレフリン潅流の散瞳維持効果", 日本眼科紀要, vol. 40, no. 8, JPN6009045153, 28 August 1989 (1989-08-28), JP, pages 1730 - 1733, ISSN: 0003351207
あたらしい眼科, vol. １９（１）, JPN6015011648, 30 January 2002 (2002-01-30), JP, pages 107 - 109, ISSN: 0003351208
日眼会誌, vol. ９６（１１）, JPN6015011653, 1992, JP, pages 1379 - 1386, ISSN: 0003351209
西出忠之, 他.: "強度近視白内障手術での０．２％リドカイン眼内灌流麻酔法", 臨床眼科, vol. 53, no. 5, JPN6009045155, 15 May 1999 (1999-05-15), JP, pages 921 - 922, ISSN: 0003351210
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita