To provide an oral dosage form of an opioid analgesic having lowered abuse risk by oral administration compared with commercially available conventional dosage forms.
There is provided an oral dosage form comprising a combination of an analgesically effective amount of an opioid agonist in oral administration and an orally active opioid antagonist, and the opioid antagonist is included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of the opioid antagonist included in the combination product provides at least a mildly negative "aversive" experience in physically dependent drug addicts (e.g., precipitated abstinence syndrome).
COLUCCI ROBERT D
| JPH08510752A | 1996-11-12 |
| WO1997033566A2 | 1997-09-18 | |||
| US4457933A | 1984-07-03 |
JPN6013029613; 医薬品添加物事典 , 1994, ｐ．１８１
JPN6010059751; 新・薬剤学総論（改訂第３版） , 1987, ｐ．１４９-１５０
Eiji Katayama
Norio Omori
Kyoei Sugiyama
Yasuhito Suzuki