OPTICAL ISOMER OF TENATOPRAZOLE AND USE THEREOF IN MEDICAL TREATMENT

Title:

OPTICAL ISOMER OF TENATOPRAZOLE AND USE THEREOF IN MEDICAL TREATMENT

Document Type and Number:

Japanese Patent JP2011137014

Kind Code:

A

Abstract:

To provide an antiulcer drug having a prolonged activity retention time, unlike proton pump inhibitors such as omeprazole or lansoprazole.

An optically active material of tenatoprazole, (+) and (-)-5-methoxy-2-{[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]sulfinyl}-1H-imidazo[4,5-b]pyridine, and a medical drug composition containing the same are useful for the treatment of atypical esophagus disorders such as gastroesophageal reflux disease, bleeding in the digestive system and indigestion.

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Inventors:

YAMASHITA SETSUO
EBINA KENGO

Application Number:

JP2011025757A

Publication Date:

July 14, 2011

Filing Date:

February 09, 2011

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Assignee:

MITSUBISHI TANABE PHARMA CORP

International Classes:

C07D471/04; A61K31/437; A61P1/00; A61P1/04; C07B53/00; C07B61/00

Domestic Patent References:

JPS59167587A

1984-09-21

Other References:

JPN6010036230; Ｍｅｔｈｏｄｓ　Ｆｉｎｄ．　Ｅｘｐ．　Ｃｌｉｎ．　Ｐｈａｒｍａｃｏｌ．２１, 1999, １７９-１８７
JPN6010036231; Ｍｅｔｈｏｄｓ　Ｆｉｎｄ．　Ｅｘｐ．　Ｃｌｉｎ．　Ｐｈａｒｍａｃｏｌ．２１, 1999, １１５-１２２
JPN6010036232; Ｊ．　Ｐｈａｒｍ．　Ｐｈａｒｍａｃｏｌ．５１, 1999, ４５７-４６４
JPN6010036233; Ｊ．　Ｃｈｒｏｍａｔｏｇｒａｐｈｙ　Ａ６６０, 1994, ２６９-２７３
JPN6010036234; Ｃｈｒｏｍａｔｏｇｒａｐｈｙ２３, 2002, １０７-１０８
JPN6010036235; Ｉｎｔｅｒｎａｔｉｏｎａｌ　Ｌａｂ．１７, 1987, ６６-７１
JPN6010036236; Ａｍｅｒｉｃａｎ　Ｌａｂ．１９, 1987, ７２-７６

Attorney, Agent or Firm:

Hideto Yagi

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