アムロジピンの光学分離方法

Title:

アムロジピンの光学分離方法

Document Type and Number:

Japanese Patent JP5124281

Kind Code:

B2

Abstract:

The present invention relates to a method for optical resolution of amlodipines by using isopropanol solvent and optically active O,O′-dibenzoyl tartaric acid as chiral reagent. More particularly, the present invention relates to a method comprising (a) obtaining (R)- or (S)-amlodipine dibenzoyl tartrate salt or solvate thereof by reacting (R,S)-amlodipines with optically active O,O′-dibenzoyl tartaric acid in isopropanol solvent, and (b) treating the (R)- or (S)-amlodipine salt with a base, thus obtaining optically active amlodipine.

Inventors:

Kim Jae Sung
Choi Jin Yun
Kim Nam Ho
Lee Nam Cue

Application Number:

JP2007544270A

Publication Date:

January 23, 2013

Filing Date:

December 02, 2005

Export Citation:

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