Title:
OPTICAL RESOLUTION OF RACEMIC MIXTURE OF A-NAPHTHYLPROPIONICACID
Document Type and Number:
Japanese Patent JPS60132930
Kind Code:
A
Abstract:
A new process for the optical resolution of racemic mixtures of α-naphthyl-propionic acids of formulaThis process comprises reacting a racemic mixture of a compound of formulawith an optically active substance of formula R4-NH2 (III), said substance being a β-aminoalcohol, thus forming a pair of diastereoisomeric amides which are resolved into the single diastereoisomers by fractional crystallization. The obtained single diastereoisomeric amide is then hydrolized to give the desired optically active α-naphthyl-propionic acid of formulaIn the above compound I → III and VI, R, is (C1-6)alkyl, R2 stands for hydrogen, halogen, mercapto, (C1-6)alkylthio, phenylthio, benzylthio (C1-6)alkylsulfonyl, benzenesulfonyl, benzenesulfonyl substituted by halogen or (C1-4)alkyl, R3 is a reactive group and R4 is the residue of a primary or secondary alcohol.
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Inventors:
CANNATA VINZENZO (IT)
TAMERLANI GIANCARLO (IT)
TAMERLANI GIANCARLO (IT)
Application Number:
JP24787484A
Publication Date:
July 16, 1985
Filing Date:
November 22, 1984
Export Citation:
Assignee:
ALFA CHEM ITAL (IT)
International Classes:
C07B31/00; C07B57/00; C07C51/00; C07C51/06; C07C67/00; C07C69/736; C07C231/00; C07C231/02; C07C59/64; C07C231/12; C07C231/20; C07C235/32; C07C309/73; C07C313/00; C07C315/06; C07C317/46; C07C323/20; C07C323/62; C07D233/56; (IPC1-7): C07B57/00; C07C51/06; C07C59/64; C07C102/04; C07C103/76; C07C147/11; C07C149/24; C07C149/40
Domestic Patent References:
| JPS5695149A | 1981-08-01 |
Attorney, Agent or Firm:
Sota Asahina (2 outside)