NEW MATERIAL:Optically active cephalosporin analogs of formula I (R1 is H, lower alkyl; R2 is H, residual group of ester hydrogen atoms in the 6 and 7 positions are in cis configuration.) and their salts.
EXAMPLE: (+)-7β-Amino-1-azabicyclo[4,2,0]oct-2-ene-8-one-2-carboxylic acid.
USE: Antibiotic; the acylated compounds show very strong antibacterial activity compared with the corresponding inactive derivative.
PREPARATION: The compound of formula II (R is substituted or unsubstituted unsaturated carbon-six-membered or hetero-5-membered ring; X is H, amino, hydroxyl, lower alkyl) is subjected to optically active deacylation using a microorganism belonging to Aeromonas and only the one of optically active enantiomers is separated in high yield. This process is quite new.
HASHIMOTO YUKIO
OGASA TAKEHIRO
KOBAYASHI SHIGERU
MATSUKUMA MASAO
KIMURA KAZUO
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