OPTICALLY ACTIVE COMPOUND OF MESYLATE TRIHYDRATE SALT OF 1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDIN-1-YL)-1-PROPANOL

Title:

OPTICALLY ACTIVE COMPOUND OF MESYLATE TRIHYDRATE SALT OF 1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDIN-1-YL)-1-PROPANOL

Document Type and Number:

Japanese Patent JP2004196823

Kind Code:

A

Abstract:

To provide a optically active compound of mesylate trihydrate salt of (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol compound represented by formula (I).

The optically active substance of the compound is produced by a method for producing mesylate trihydrate salt of a compound represented by formula (I), wherein the method comprises steps of (i) dissolving D-(-)-tartrate salt of a compound represented by formula (I) in an aqueous solution of methanesulfonic acid and (ii) separating the methanesulfonate trihydrate from the solution.

Inventors:

RAINVILLE JOSEPH PHILIP
SINAY TERRY GENE JR
WALINSKY STANLEY WALTER

Application Number:

JP2004071015A

Publication Date:

July 15, 2004

Filing Date:

March 12, 2004

Export Citation:

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Assignee:

PFIZER PROD INC

International Classes:

A61K31/445; A61K31/451; A61P3/08; A61P9/10; A61P13/02; A61P21/00; A61P21/02; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/28; A61P25/30; A61P25/32; A61P29/00; A61P31/18; A61P43/00; C07B57/00; C07D211/52; (IPC1-7): C07D211/52; A61P3/08; A61P9/10; A61P13/02; A61P21/02; A61P25/00; A61P25/04; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/28; A61P25/32; A61P31/18

Attorney, Agent or Firm:

Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Kiyoshi Murakami

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