NEW MATERIAL: The compound of formula I in the form of a single stereoisomer [wherein Ar is 6-methoxy-2-naphthyl; R1 is alkyl, cycloalkyl; R3 and R4 are alkyl, or they are combined to form 2-8C alkylene; Z is a leaving group or a group convertible into a leaving group, particularly halogen, OH, acetoxy, benzoyloxy, dihydropyanyloxy, trialkylsiloxy, formula II (wherein R2 is alkyl, cycloalkyl, alkenyl, alkynyl, aryl, aralkyl, provided that when R1, R3 and R4 are methyl, R2 is not d-10-camphoryl)].
EXAMPLE: (S) 2-Chloro-1,1-dimethoxy-1-(6-methoxy-2-naphtyl)propane.
USE: An intermediate for stereoselective preparation of optically active α- arylalkanoic acid active as an antiphlogistic, etc.
PROCESS: Ketone of formula IV, obtained by allowing the compound of formula ArMX to react with the compound of formula III, is brought into contact with a ketelizing agent to prepare the compound of the formula V. Then, the leaving group is regenerated at the α-position of the compound of formula V to obtain the compound of formula I.
| JPS56135444A | 1981-10-22 | |||
| JPS5798232A | 1982-06-18 | |||
| JPS57192325A | 1982-11-26 |
Next Patent: OPTICALLY ACTIVE KETONE