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Title:
OPTICALLY ACTIVE NOVEL THIAZOLIDINE-4-ONE DERIVATIVE AND ACID-ADDITION SALT THEREOF
Document Type and Number:
Japanese Patent JPH01190679
Kind Code:
A
Abstract:

NEW MATERIAL:A compound expressed by formula I [Ar is aryl (substituted by halogen or lower alkoxy); X is straight-chain or branched chain lower alkylene or single bond; R is H, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, acyloxy, OH, aryl, etc.; Py is pyridyl] and acid-addition salt thereof.

EXAMPLE: (+)-cis-5-(4-Chlorophenyl)-3-methyl-2-(3-pyridyl)-thiazolidine-4-one.

USE: A medicine and active ingredient for anti-platelet-activating factor agent. Useful as a medicine for preventing and treating an induced disease such as allergic disease, circulatory disease or alimentary disease.

PREPARATION: For example, an optically active compound expressed by formula II is reacted with a compound expressed by formula III in an organic solvent to close a ring and the resultant mixture of cis isomer and trans isomer is readily separated to cis isomer and trans isomer by conventional separation means to provide the compound expressed by formula I.


Inventors:
ENOMOTO MASAO
MURAOKA MASAMI
ONO KEIICHI
KOJIMA ATSUYUKI
ATAMI TOSHIO
KOMURO YOSHIHIRO
SANEMITSU MINORU
MIZUTANI MASATO
TANABE AKIRA
Application Number:
JP1244488A
Publication Date:
July 31, 1989
Filing Date:
January 22, 1988
Export Citation:
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Assignee:
SUMITOMO PHARMA
SUMITOMO CHEMICAL CO
International Classes:
C07D213/53; A61K31/44; A61K31/4406; A61K31/4418; A61P1/04; A61P7/02; A61P11/00; A61P29/00; C07D417/04; (IPC1-7): A61K31/44; C07D213/53; C07D417/04
Attorney, Agent or Firm:
Akira Asamura (3 outside)