OPTICALLY ACTIVE TARTARIC ACID ESTER OF ALKANOL AMINE, PREPARATION, USE AND PREPARATION OF OPTICALLY PURE ALCOHOL

Title:

OPTICALLY ACTIVE TARTARIC ACID ESTER OF ALKANOL AMINE, PREPARATION, USE AND PREPARATION OF OPTICALLY PURE ALCOHOL

Document Type and Number:

Japanese Patent JPS6048954

Kind Code:

A

Abstract:

For the analytical and preparative separation of the optical isomers of optically active alkanolamines into their optically pure antipodes a new resolution method is presented which involves an ester formation of the alkanolamines with optically pure and symmetrically O,O disubstituted (R,R)- or (S,S)-tartaric acids. The derivitization reactions are carried out in aprotic solvents and the primary and secondary functions are blocked via ion-pair formations with strong acids, e.g. dichloroacetic acid. The tartaric acid anhydrides are predominantly used as reagents but other ester formation methods are also practicable. The mixture of the diastereomeric alkanolamine tartaric acid monoesters are separable into their optically active and pure isomers by various chromotographic separation techniques, e.g. straight or reverse phase LC, but also by extraction methods e.g. Soxhlet extraction. The optically pure parent alkanolamine isomers can be obtained by ester hydrolysis, with high yield, from the optically pure fractions of the alkanolamine tartaric acid monoesters.

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Inventors:

LINDNER WOLFGANG

Application Number:

JP3226484A

Publication Date:

March 16, 1985

Filing Date:

February 22, 1984

Export Citation:

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Assignee:

LINDNER WOLFGANG

International Classes:

C07C9/00; C07B31/00; C07B57/00; C07C67/00; C07C213/00; C07C213/10; C07C215/08; C07C215/28; C07C219/02; C07C219/06; C07C219/18; C07C219/20; C07C219/22; C07C233/16; C07C235/06; C07C237/00; C07C237/08; C07C237/30; C07C237/32; C07C251/44; C07C253/00; C07C255/54; C07C275/38; C07C301/00; C07C303/30; C07C303/34; C07C309/63; C07C311/00; C07D207/12; C07D209/08; C07D209/88; C07D211/42; C07D285/10; C07D295/08; C07D307/78; (IPC1-7): C07B57/00; C07C89/00; C07C91/02; C07C91/28; C07C93/187; C07C93/233; C07C93/24; C07C93/26; C07C103/26; C07C103/38; C07C103/42; C07C103/50; C07C121/75; C07C127/19; C07C131/08; C07C143/68; C07C143/75; C07D207/12; C07D209/08; C07D209/88; C07D211/42; C07D285/10; C07D307/78

Attorney, Agent or Firm:

Fujiya Shiga

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