Title:
活性ボツリヌス毒素A型の発現の最適化
Document Type and Number:
Japanese Patent JP2008508886
Kind Code:
A
Abstract:
Nucleic acid molecules that comprise modified open reading frames providing increased expression of the encoded active BoNT/A in a heterologous cell, expression constructs and cells comprising such nucleic acid molecules and methods useful for expressing the encoding active BoNT/A from such nucleic acid molecules, expression constructs and cells.
Inventors:
Lance E Steward
Marcella A. Gilmore
Esther e Fernandez-Salas
Shen Wen Li
Ronald G. Miller
Kay Roger Aoki
Marcella A. Gilmore
Esther e Fernandez-Salas
Shen Wen Li
Ronald G. Miller
Kay Roger Aoki
Application Number:
JP2007525034A
Publication Date:
March 27, 2008
Filing Date:
August 03, 2005
Export Citation:
Assignee:
ALLERGAN,INCORPORATED
International Classes:
C12N15/09; C12N1/19; C12N1/21; C12N5/10
Domestic Patent References:
| JP2003137897A | 2003-05-14 |
Foreign References:
| WO2000067700A2 | 2000-11-16 |
Other References:
GENE, vol. 315, JPN6011005605, 2003, pages 21 - 32, ISSN: 0001840341
TOXICON, vol. 36, no. 11, JPN6011005607, 1998, pages 1539 - 1548, ISSN: 0001840342
TRENDS. BIOTECHNOL., vol. 22, no. 7, JPN6011005611, July 2004 (2004-07-01), pages 346 - 353, ISSN: 0001840343
TOXICON, vol. 36, no. 11, JPN6011005607, 1998, pages 1539 - 1548, ISSN: 0001840342
TRENDS. BIOTECHNOL., vol. 22, no. 7, JPN6011005611, July 2004 (2004-07-01), pages 346 - 353, ISSN: 0001840343
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga