最適化第ＶＩＩＩ因子遺伝子 - Bioverativ Therapeutics Incorporated

Title:

最適化第ＶＩＩＩ因子遺伝子

Document Type and Number:

Japanese Patent JP7217630

Kind Code:

B2

Abstract:

The present disclosure provides codon optimized Factor VIII sequences, vectors, and host cells comprising codon optimized Factor VIII sequences, polypeptides encoded by codon optimized Factor VIII sequences, and methods of producing such polypeptides. The present disclosure also provides methods of treating bleeding disorders such as hemophilia comprising administering to the subject a codon optimized Factor VIII nucleic acid sequence or the polypeptide encoded thereby.

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Inventors:

Thanh, Siyuan
Liu, Tongyao

Application Number:

JP2018539962A

Publication Date:

February 03, 2023

Filing Date:

January 31, 2017

Export Citation:

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Assignee:

Bioverativ Therapeutics Incorporated

International Classes:

C12N15/12; A61K31/7088; A61K35/76; A61K38/37; A61K48/00; A61P7/04; C07K14/755; C07K14/76; C07K14/79; C07K16/00; C07K19/00; C12N5/10; C12N15/62; C12N15/63; C12N15/867; C12P21/02

Domestic Patent References:

JP2015509365A

Foreign References:

US20130017997
WO2011005968A1
WO2016004113A1

Attorney, Agent or Firm:

Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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