Title:
Ｃｈｒｉｍｓｏｎを用いた光遺伝学的視覚回復
Document Type and Number:
Japanese Patent JP6942789
Kind Code:
B2
Abstract:
Disclosed are, among other methods, methods for reactivating retinal ganglion cells in mammals by administering an effective amount of channelrhodopsins (such as ChrimsonR), or an effective amount of such channelrhodopsins (such as ChrimsonR) fused to a fluorescent protein, in the form of protein or nucleic acids, and compositions thereof. The methods may include a light stimuli level inducing RGCs response that is below radiation safety limit. The methods may include delivery by an adenoassociated virus vector. The methods may include use of a CAG promoter. The methods may result in a long term expression of an effective amount of the channelrhodopsins (such as ChrimsonR protein).
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Inventors:
Pruneau Didier
Douard Anne
Dalcala Deniz
Dobel Jens
Caplet romance
Gorvan Gregory
Delose's Melissa
Sahel Jose
Pico Serge
Douard Anne
Dalcala Deniz
Dobel Jens
Caplet romance
Gorvan Gregory
Delose's Melissa
Sahel Jose
Pico Serge
Application Number:
JP2019508309A
Publication Date:
September 29, 2021
Filing Date:
April 28, 2017
Export Citation:
Assignee:
Gensite Biologics S
SORBONNE UNIVERSITE
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Anstitu National de la Sainte de la Recherche Medical (JNES ere M)
SORBONNE UNIVERSITE
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Anstitu National de la Sainte de la Recherche Medical (JNES ere M)
International Classes:
A61K38/16; A61K35/76; A61P9/10; A61P25/00; A61P25/02; A61P27/02; A61P43/00; C12N5/10; C12N15/864; C12Q1/6897
Foreign References:
| WO2013071231A1 |
Other References:
Nat Methods.,2014年,Vol. 11, No. 3,p. 338-346
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office