Title:
口腔内崩壊型組成物及び口腔内崩壊型製剤
Document Type and Number:
Japanese Patent JP4802436
Kind Code:
B2
Abstract:
Compositions quickly disintegrating in the oral cavity which contain a filler comprising a sugar alcohol, a disintegrating agent and a lubricant. The penetration rate of ethanol into this lubricant is 3.0 x 10<-3>g<2>/sec or above. The tablet strength is 20 N or above. The compositions disintegrate in the oral cavity of normal adults within 90 seconds. Preparations disintegrating in the oral cavity which are prepared by adding drug components to these compositions disintegrating in the oral cavity. Thus, both of an appropriate strength needed in handling the preparations and quick disintegration in the oral cavity can be achieved without resort to any special production procedures or instruments.
Inventors:
Narushima Masato
Aizawa Kazutoshi
Hiroshi Shimoyama
Kiyofumi Ishikawa
Aizawa Kazutoshi
Hiroshi Shimoyama
Kiyofumi Ishikawa
Application Number:
JP2001574083A
Publication Date:
October 26, 2011
Filing Date:
April 11, 2001
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
A61K9/20; A61K9/00; A61K47/04; A61K47/10; A61K47/12; A61K47/14; A61K47/36; A61K47/38; A61K47/44; A61P1/00; A61P3/00; A61P5/00; A61P7/00; A61P9/00; A61P11/00; A61P13/00; A61P25/00; A61P27/00; A61P31/00; A61P35/00; A61P37/00; A61P43/00
Domestic Patent References:
| JPH09194381A | 1997-07-29 | |||
| JPH10287555A | 1998-10-27 | |||
| JPH03227916A | 1991-10-08 | |||
| JPH08291051A | 1996-11-05 | |||
| JP2000044463A | 2000-02-15 |