Title:
抗微生物化合物の有機酸化窒素供与体塩、組成物、および使用法
Document Type and Number:
Japanese Patent JP2008530226
Kind Code:
A
Abstract:
The invention describes novel organic nitric oxide donor salts of a antimicrobial compounds, and novel compositions and kits comprising at least one organic nitric oxide donor salt of an antimicrobial compound, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating bacterial infections; (b) treating viral infections; (c) treating fungal infections; and (d) treating lesions. In one embodiment the antimicrobial compounds of the invention are aztreonam, ciprofloxacin, doripenam, duramycin and tobramycin. The organic nitric oxide donors that form salts are preferably organic nitrates, organic nitrites, nitrosothiols, thionitrites and heterocyclic nitric oxide donors. The heterocyclic nitric oxide donors are preferably furoxans, sydnonimines, oxatriazole-5-ones and/or oxatriazole-5-imines. The methods of the invention are preferably for the treatment of bacterial infections associated with pulmonary diseases such as cystic fibrosis and for treating Bacillus anthracis infections.
Inventors:
Ellis James Elle.
Garvey David S.
Lin Chi-en.
Garvey David S.
Lin Chi-en.
Application Number:
JP2007556278A
Publication Date:
August 07, 2008
Filing Date:
February 16, 2006
Export Citation:
Assignee:
Nitromed Incorporated
International Classes:
C07H5/06; A61K31/407; A61K31/427; A61K31/47; A61K31/4709; A61K31/4741; A61K31/4745; A61K31/702; A61K45/06; A61P31/00; A61P31/10; A61P31/12; C07D215/54; C07D401/02; C07D417/12; C07D471/04; C07D477/00; C07D498/04
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi