大理石骨病発症モデル非ヒト動物 - Japan Science and Technology Agency

Title:

大理石骨病発症モデル非ヒト動物

Document Type and Number:

Japanese Patent JP5230893

Kind Code:

B2

Abstract:

To provide a non-human animal developing osteopetrosis by trouble in differentiation induction of bone marrow cell to osteoclast, and to provide a method for screening a substance promoting or suppressing differentiation induction of bone marrow cell to osteoclast, and the like, by using the osteopetrosis onset model non-human animal.

A double knockout non-human animal (DKO) defected in gene function is obtained by defecting or mutating a gene coding membrane adaptor molecule DNAX activating protein DAP12 supporting immunologically activating signal transfer and a gene encoding Fc acceptor common γ subunit FcRγ. The differentiation induction-promoting or suppressing substance of bone marrow cell to osteoclast, or, bone metabolism promoting or suppressing substance is screened by using osteopetrosis onset DAP 12 and FcRγ gene double knockout non-human animal.

Inventors:

Toshiyuki Takai
Hiroshi Takayanagi
Dry rule
Takako Koga

Application Number:

JP2004108206A

Publication Date:

July 10, 2013

Filing Date:

March 31, 2004

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Japan Science and Technology Agency

International Classes:

A01K67/027; C12N5/07; C12N5/0735; C12N5/077; C12N5/078; C12N15/09; C12Q1/02; G01N33/15; G01N33/50

Domestic Patent References:

JP2004154132A

Other References:

Cell,76(1994),p.519-529
Gene.Dev.,1999,13,p.2412-2424
Arch.Oral Biol.,1999,44,p.81-88

Attorney, Agent or Firm:

Masaki Hirota

Previous Patent: JPS5230892

Next Patent: WOOD FRAME BODY FOR BUILDING