Title:
一過性受容体電位型チャネル阻害剤としてのオキサジアゾロン類
Document Type and Number:
Japanese Patent JP7171567
Kind Code:
B2
Abstract:
and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and methods of using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as respiratory disorders or pain.
Inventors:
Beaumiers, Francis
Chen, Huifen
Clydeland, Andrew
Durie, martin
Huh, By Hua
La Roche-Gautier, Robin
Rou, Aijun
Shore, daniel
Wilmühle, Elysia
Volgraph, Matthew
Ward, stewart
Chen, Huifen
Clydeland, Andrew
Durie, martin
Huh, By Hua
La Roche-Gautier, Robin
Rou, Aijun
Shore, daniel
Wilmühle, Elysia
Volgraph, Matthew
Ward, stewart
Application Number:
JP2019527497A
Publication Date:
November 15, 2022
Filing Date:
November 27, 2017
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D471/04; A61K31/5025; A61K31/519; A61K31/522; A61K31/53; A61P1/00; A61P1/04; A61P11/00; A61P11/06; A61P11/14; A61P13/02; A61P17/00; A61P19/02; A61P27/16; A61P29/00; A61P43/00; C07D473/30; C07D487/04; C07D498/04; C07D513/04
Domestic Patent References:
| JP2010522723A |
Foreign References:
| WO2011114184A1 | ||||
| WO2017060488A1 |
Other References:
SCHENKEL, Laurie B.,J.Med.Chem.,2016年,59,2794-2809
MONGE, A.,J. Heterocyclic Chem.,1984年,21(2),397 - 400
PATEL, Syham Sunder,Org.Biomol.Chem.,2016年,14(24),5683 - 5689,http://dx.doi.org/10.1039/C5OB02667A
MUSSER, John H.,J.Med.Chem.,1984年,27,121-125
SUGIMOTO, Osamu,Chem.Commun.,2014年,50(55),7314 - 7317,http://dx.doi.org/10.1039/C4CC01971G
PubChem CID: 3437423,Database PubChem [ONLINE],2005年09月08日,https://pubchem.ncbi.nlm.nih.gov/compound/3437423,7-[[4-[(2-METHOXYPHENYL)METHYL]-5-OXO-1,3,4-OXADIAZOL-2-YL]METHYL]-1,3-DIMETHYLPURINE-2,6-DIONE
CAS Registry No.1381342-13-7,File REGISTRY [online], STN International,Entered STN,2012年07月04日,3-(2-Pyridinylmethyl)-5-(5-quinolinyl)-1,3,4-oxadiazol-2(3H)-one
CAS Registry No. 887037-04-9,File REGISTRY [online], STN International,Entered STN,2006年06月07日,3-[2-(4-Methoxyphenyl)ethyl]-5-(5-quinolinyl)-1,3,4-oxadiazol-2(3H)-one
MONGE, A.,J. Heterocyclic Chem.,1984年,21(2),397 - 400
PATEL, Syham Sunder,Org.Biomol.Chem.,2016年,14(24),5683 - 5689,http://dx.doi.org/10.1039/C5OB02667A
MUSSER, John H.,J.Med.Chem.,1984年,27,121-125
SUGIMOTO, Osamu,Chem.Commun.,2014年,50(55),7314 - 7317,http://dx.doi.org/10.1039/C4CC01971G
PubChem CID: 3437423,Database PubChem [ONLINE],2005年09月08日,https://pubchem.ncbi.nlm.nih.gov/compound/3437423,7-[[4-[(2-METHOXYPHENYL)METHYL]-5-OXO-1,3,4-OXADIAZOL-2-YL]METHYL]-1,3-DIMETHYLPURINE-2,6-DIONE
CAS Registry No.1381342-13-7,File REGISTRY [online], STN International,Entered STN,2012年07月04日,3-(2-Pyridinylmethyl)-5-(5-quinolinyl)-1,3,4-oxadiazol-2(3H)-one
CAS Registry No. 887037-04-9,File REGISTRY [online], STN International,Entered STN,2006年06月07日,3-[2-(4-Methoxyphenyl)ethyl]-5-(5-quinolinyl)-1,3,4-oxadiazol-2(3H)-one
Attorney, Agent or Firm:
Patent Attorney Corporation Tsukuni