Title:
甲状腺受容体リガンドとしてのオキサミド酸類及びその誘導体類
Document Type and Number:
Japanese Patent JP3699355
Kind Code:
B2
Abstract:
The present invention provides novel compounds of the Formula and prodrugs thereof, geometric and optical isomers thereof, and pharmaceutically acceptable salts of such compounds, prodrugs and isomers, wherein R1-R8 and W are as described herein. Pharmaceutical compositions containing such compounds, prodrugs, isomers or pharmaceutically acceptable salts thereof, and methods, pharmaceutical compositions and kits for treating obesity, hyperlipidemia, glaucoma, cardiac arrhythmia, skin disorders, thyroid disease, hypothyroidism and related disorders and diseases such as diabetes mellitus, atherosclerosis, hypertension, coronary heart disease, hypercholesteremia, depression and osteoporosis are also provided.
Inventors:
Chang, Yuan-Chin Phoebi
Dow, Robert Lee
Dow, Robert Lee
Application Number:
JP2000602199A
Publication Date:
September 28, 2005
Filing Date:
February 21, 2000
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
A61K31/10; A61K31/165; A61K31/167; A61K31/18; A61K31/198; A61K31/223; A61K31/36; A61K31/381; A61K31/40; A61K31/404; A61K31/445; A61K31/4453; A61K31/47; A61K31/472; A61K31/5375; A61K31/55; C07D295/08; A61P3/04; A61P3/06; A61P3/10; A61P5/14; A61P5/16; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P17/00; A61P19/10; A61P25/24; A61P27/06; A61P43/00; C07C233/56; C07C235/60; C07C235/74; C07C311/29; C07C317/22; C07C317/50; C07C323/41; C07D209/08; C07D209/32; C07D211/14; C07D211/16; C07D211/22; C07D215/08; C07D215/20; C07D217/04; C07D217/06; C07D217/08; C07D233/20; C07D295/096; C07D295/16; C07D295/192; C07D295/22; C07D295/26; C07D317/54; C07D317/58; C07D317/68; C07D333/20; C07D333/22; C07D333/36; (IPC1-7): C07C311/29; C07C317/22; C07D209/32
Other References:
N.Yokoyama et al,Synthesis and Structure-Activity Relationships of Oxamic Acid and Acetic Acid Derivatives・・・,Journal of Medicinal Chemistry,米国,American Chemical Society, Washington,1995年,38巻4号,p.695-707
Taylor A.H. et al,Beneficial Effects of a Novel Thyromimetic on Lipoprotein Metabolism,Molecular Pharmacology,米国,The American Society for Pharmacology・・・,1997年,52巻3号,p.542-547
Taylor A.H. et al,Beneficial Effects of a Novel Thyromimetic on Lipoprotein Metabolism,Molecular Pharmacology,米国,The American Society for Pharmacology・・・,1997年,52巻3号,p.542-547
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji