Title:
ＰＡＲＰ（ＡＤＰ−リボシルトランスフェラーゼ、ＡＤＰＲＴ）および修復酵素として有用なベンズアミド類似体
Document Type and Number:
Japanese Patent JPH09510704
Kind Code:
A
Abstract:
A range of quinazolinone compounds are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA-damaging cytotoxic drugs or radiotherapy to potentiate the effects of the latter. The compounds disclosed comprise certain quinazolinone compounds having the general structural formula II or pharmaceutically acceptable salt thereof,characterised in thatX' represents hydroxyl, alkyl, alkoxy or an optionally substituted aryl (e.g. phenyl) or aralkyl (e.g. benzyl) group,andY' represents hydrogen, alkyl or an optionally substituted aryl (e.g. phenyl) or aralkyl (e.g. benzyl) group.
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Inventors:
A car tongue, NICOLA Jay
Calvert, A Hillary
Griffin, Roger John
Golding, Bernhard Tea
Newell, David An R
Calvert, A Hillary
Griffin, Roger John
Golding, Bernhard Tea
Newell, David An R
Application Number:
JP52331695A
Publication Date:
October 28, 1997
Filing Date:
March 09, 1995
Export Citation:
Assignee:
New Castle A university ベンチャーズ The Limited
International Classes:
A61K31/135; A61K31/275; A61K31/357; A61K31/36; A61K31/39; A61K31/42; A61K31/423; A61K31/496; A61K31/505; A61K31/517; A61K45/00; A61N5/00; A61P35/00; A61P43/00; C07D239/90; C07C235/46; C07C247/16; C07C255/54; C07D239/91; C07D263/56; C07D263/57; C07D317/54; C07D317/68; C07D327/04; C07D473/34; C07D473/40; (IPC1-7): C07C235/46; A61K31/135; A61K31/275; A61K31/36; A61K31/42; A61K31/505; A61K45/00; A61N5/00; C07D239/90; C07D263/56; C07D317/54; C07D473/34
Attorney, Agent or Firm:
Kono Showa