Title:
延長された生体内半減期を有するPEG-生理活性ポリペプチド同種二量体結合体及びその製造方法
Document Type and Number:
Japanese Patent JP2007528347
Kind Code:
A
Abstract:
A PEG-polypeptide homodimer complex, which comprises a PEG linker and two molecules of a physiologically active polypeptide, wherein the two molecules of the physiologically active polypeptide are connected via the PEG linker, and each of the two molecules of the physiologically active polypeptide is modified with one molecule of PEG, is useful for the development of a polypeptide drug having a prolonged half-life in the blood.
Inventors:
Kim, Yoon Min
Kim, De Jin
Bae, Sun Min
Rim, Chang Ki
Kim, Kyung Bae
Kwon, Se Chan
Li, Gwang Soon
Kim, De Jin
Bae, Sun Min
Rim, Chang Ki
Kim, Kyung Bae
Kwon, Se Chan
Li, Gwang Soon
Application Number:
JP2006500669A
Publication Date:
October 11, 2007
Filing Date:
April 03, 2004
Export Citation:
Assignee:
Hammi Farm. Seeo., LDT.
International Classes:
C07K1/113; A61K47/48; C07K14/47; C07K14/475; C07K14/53; C07K14/535; C07K14/54; C07K14/555; C07K14/56; C07K14/575; C07K14/61; C07K14/62
Attorney, Agent or Firm:
Takehiko Suzue
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Ryo Hashimoto
Tetsuya Kazama
Satoshi Kono
Makoto Nakamura
Kurata Masatoshi
Takashi Mine
Yoshihiro Fukuhara
Toshio Shirane
Sadao Muramatsu
Nobuhisa Nogawa
Ryo Hashimoto
Tetsuya Kazama