Title:
Ｂ型肝炎抗原タンパク質を標的としたイメージング用ＰＥＴプローブ
Document Type and Number:
Japanese Patent JP7072213
Kind Code:
B2
Abstract:
To provide a method of observing hepatitis B virus (HBV) in a liver noninvasively.SOLUTION: The present invention provides an imaging PET probe targeting hepatitis B antigen protein, containing a compound represented by the following formula (I) or a salt thereof. [Ris a C3-7 cyclohexyl group, a naphthyl group, a phenyl group or a substituted phenyl group; Ris a phenyl group or a substituted phenyl group; Ris a 1,3-phenylene group in which the second position is optionally substituted with halogen, or a pyridine-2,6-diyl group; the compound is labeled withC, or, when containing a fluorine atom, it is labeled withF].SELECTED DRAWING: Figure 6
Inventors:
Niwa Bushi
Yuta Uetake
Hideki Ochiai
Takamitsu Hosoya
Yosuke Kanayama
Kyoyoshi Watanabe
Soichi Kojima
Kenji Ogawa
Yasue Ichikawa
Yuta Uetake
Hideki Ochiai
Takamitsu Hosoya
Yosuke Kanayama
Kyoyoshi Watanabe
Soichi Kojima
Kenji Ogawa
Yasue Ichikawa
Application Number:
JP2017245355A
Publication Date:
May 20, 2022
Filing Date:
December 21, 2017
Export Citation:
Assignee:
RIKEN
International Classes:
C07C233/64; A61K51/04; C07C233/66; C07C233/75; C07C233/80; C07C255/60; C07C321/28; C07D213/81; C07F5/02; C07F7/12; C12Q1/16; G01N33/569; G01N33/576; G01N33/58
Domestic Patent References:
| JP2002521437A | ||||
| JP8510635A |
Foreign References:
| WO2020255425A1 | ||||
| WO2004022585A1 |
Other References:
Angew Chem Int Ed Engl,2005年,Vol. 44, No. 35,p. 5725-5729,doi: 10.1002/anie.200500982
Attorney, Agent or Firm:
Patent business corporation Ikeuchi and Partners
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