Title:
PHARMACEUTICAL COMPOSITION INCLUDING IMMUNOGLOBULIN Fc REGION AS CARRIER
Document Type and Number:
Japanese Patent JP2012224635
Kind Code:
A
Abstract:
To provide novel application of an immunoglobulin Fc region, more specifically, a pharmaceutical composition including the immunoglobulin Fc region as a carrier.
The pharmaceutical composition including the immunoglobulin Fc region as a carrier of a drug greatly increases a half-life of the coupled drug in blood while maintaining comparatively high in-vivo activity of the coupled drug. When the drug is a polypeptide drug, risk of immunoreactivity induction is reduced in comparison with a fusion protein of the immunoglobulin Fc region and a target protein. Consequently, application useful for development of long-acting pharmaceutical preparations of various polypeptide drugs is provided.
Inventors:
KIM YOUNG MIN
SONG DAE HAE
JUNG SUNG YOUB
KIM CHAN FAN
CHOI IN YOUNG
KWON SE CHANG
LEE GWAN SUN
SONG DAE HAE
JUNG SUNG YOUB
KIM CHAN FAN
CHOI IN YOUNG
KWON SE CHANG
LEE GWAN SUN
Application Number:
JP2012166208A
Publication Date:
November 15, 2012
Filing Date:
July 26, 2012
Export Citation:
Assignee:
HANMI SCIENCE CO LTD
International Classes:
A61K39/395; A61K47/42; A61K38/00; A61K38/21; A61K38/22; A61K38/27; A61K38/43; A61K39/00; A61K47/34; A61K47/48; C07K16/00; C07K16/42; C07K19/00; C12N15/70
Attorney, Agent or Firm:
Kenzo Hara International Patent Office