Title:
前立腺癌の治療及び診断の標的遺伝子のための、PKIB及びNAALADL2
Document Type and Number:
Japanese Patent JP2010536365
Kind Code:
A
Abstract:
The invention features methods for detecting prostate cancer, especially hormone-refractory prostate cancer (HRPC) or castration-resistant prostate cancer (CRPC), by detecting over-expression of PKIB or NAALADL2 compared the normal organs. Also disclosed are methods of identifying compounds for treating and preventing prostate cancer including HRPC, based on the over-expression of PKIB or NAALADL2 in the prostate cancer, the cell proliferation function of PKIB or NAALADL2, the intracellular localization of PKIB or NAALADL2 or the interaction between PKIB and PKA-C. Also, provided are a method for treating prostate cancer by administering a double-stranded molecule against the PKIB or NAALADL2 gene. The invention also provides products, including the double-stranded molecules and vectors encoding them, as well as compositions comprising the molecules or vectors, useful in the provided methods.
Inventors:
Yusuke Nakamura
Nakagawa Hidetoshi
Shuichi Nakatsuru
Nakagawa Hidetoshi
Shuichi Nakatsuru
Application Number:
JP2010521579A
Publication Date:
December 02, 2010
Filing Date:
August 20, 2008
Export Citation:
Assignee:
OncoTherapy Science Co., Ltd.
International Classes:
C12N15/09; A61K31/713; A61K48/00; A61P13/08; A61P35/00; A61P43/00; C12N15/113; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/53; G01N33/574; G01N33/68; G01N37/00
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto