Title:
【発明の名称】プロスタグランジン誘導体の合成方法
Document Type and Number:
Japanese Patent JP2670521
Kind Code:
B2
Abstract:
Method for preparing 13,14-dihydro-17-phenyl analogues of PGF2 alpha or PGE2 comprising the step of hydrogenating the double bond in an intermediate compound (I) without deoxygenation of the allylic alcohol to give one of the intermediate compounds (II, III) wherein R is hydrogen or one or more halogen, hydroxyl, cyanide, alkyl (preferably 1-4 carbon atoms), hydroxyalkyl, trifluoromethyl or aromatic or heteroaromatic substituents on the aromatic ring R1 and R2 are each hydrogen, alkyl (preferably 1-4 carbon atoms), hydroxyl, halogen or hydroxyalkyl substituents, R3 is O-alkyl or N(alkyl), P is a protecting group.
Inventors:
Wrestle, Bharam
Application Number:
JP51361891A
Publication Date:
October 29, 1997
Filing Date:
August 08, 1991
Export Citation:
Assignee:
Pharmacia and Uptjyon Actie Evolague
International Classes:
C07C405/00; C07D307/93; C07C5/00; C07D307/935; (IPC1-7): C07C405/00; C07D307/93
Attorney, Agent or Firm:
Chika Takagi (2 outside)