Title:
【発明の名称】アズラクトン官能性の高分子担体に共有結合で固定化した生理活性物質とその製法
Document Type and Number:
Japanese Patent JP3269554
Kind Code:
B2
Abstract:
A biologically active adduct support, prepared from an azlactone-functional polymeric support and biomolecules covalently immobilized thereon, is disclosed. The biomolecules are covalently immobilized in the presence of polyanionic salt using a method which achieves both high density and optimized bound specific biological activity. Preferably, the immobilization occurs in the presence of an azlactone quencher.
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Inventors:
Coleman, Patrick El
Millbras, Dean Es
Walker, Margaret M
Millbras, Dean Es
Walker, Margaret M
Application Number:
JP50077792A
Publication Date:
March 25, 2002
Filing Date:
October 22, 1991
Export Citation:
Assignee:
Minnesota Mining and Manufacturing Company
International Classes:
C07K1/22; C07K14/42; C07K14/575; C07K14/705; C07K17/08; C07K14/745; C07K16/00; C08F20/52; C08F20/58; C08F26/06; C12N11/08; G01N33/543; C12N; (IPC1-7): C12N11/08; C07K17/08; C08F20/58; C08F26/06
Domestic Patent References:
| JP2294308A |
Other References:
Ｊ．Ｃｈｒｏｍａｔｏｇｒａｐｈｙ ５１２（１９９０）ｐ．３４５−３６３
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)