Title:
PSMA targeting dendrimer
Document Type and Number:
Japanese Patent JP6275484
Kind Code:
B2
Abstract:
A dendrimer conjugate according to Formula (I), or its pharmaceutically acceptable salt, or solvate thereof: and complexes of Formula I conjugates with metals radionuclides of elements such as rhenium, technetium, yttrium, lutetium and others to provide a complex for imaging tissues or for the radiotherapeutic treatment of cancer tissue. Such complexes are specific to PSMA protein and can therefore be used in imaging or treating cancer of the prostate and other tissue where the protein is expressed.
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Inventors:
Babich, John, W.
Joyal, John, Elle.
Zimmerman, Craig
Joyal, John, Elle.
Zimmerman, Craig
Application Number:
JP2013542250A
Publication Date:
February 07, 2018
Filing Date:
December 06, 2011
Export Citation:
Assignee:
Molecular Insight Pharmaceuticals, Inc.
International Classes:
C07C275/16; A61K31/555; A61K47/50; A61K49/04; A61K51/04; A61P35/00; C07D401/12; C07D401/14; C07D403/06; C07D403/12; C07D403/14; C07F5/00
Foreign References:
| WO2010065902A2 |
Other References:
Wangler C.他4名著、Antibody-Dendrimer Conjugates:The Number,Not the Size of the Dendrimers,Determines the Immunoreactivity、Bioconjugate Chem.、American Chemical Society、2008年、Vol.19、No.4、第813~820頁
Heng Xu.他8名著、Preparation and Preliminary Evaluation of a Biotin-Targeted,Lectin-Targeted Dendrimer-Based Probe for Dual-Modality Magnetic Resonance and Fluorescence Imaging、Bioconjugate Chem.、2007年,Vol.18、No.5、第1474~1782頁
Heng Xu.他8名著、Preparation and Preliminary Evaluation of a Biotin-Targeted,Lectin-Targeted Dendrimer-Based Probe for Dual-Modality Magnetic Resonance and Fluorescence Imaging、Bioconjugate Chem.、2007年,Vol.18、No.5、第1474~1782頁
Attorney, Agent or Firm:
Hiroshi Oshino
Yutaka Nagata
Yutaka Nagata