Title:
PANCREATIC β-CELL LINE
Document Type and Number:
Japanese Patent JP2012115153
Kind Code:
A
Abstract:
To provide a cell useful for elucidating the mechanism of insulin secretion, and to provide insulin secretion inhibitors.
There is provided a pancreatic β-cell line allowing subculture, and secreting a green fluorescent protein-labeled insulin in a glucose-concentration-dependent manner. Furthermore, there are provided the insulin secretion inhibitor containing lithium chloride; an insulin secretion inhibitor containing a glycogen synthase kinase (GSK) 3β expression inhibitor; and an insulin secretion inhibitor containing GSK3β-siRNA (small-interfering RNA).
Inventors:
USUI TAKASHI
MURATA MASAYUKI
KANO FUMI
TSUBOI TAKASHI
MURATA MASAYUKI
KANO FUMI
TSUBOI TAKASHI
Application Number:
JP2010265123A
Publication Date:
June 21, 2012
Filing Date:
November 29, 2010
Export Citation:
Assignee:
NIKKYO TECHNOS KK
UNIV TOKYO
UNIV TOKYO
International Classes:
C12N5/10; A61K33/14; A61P3/08; A61P5/48; C12N15/09
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
Toshifumi Onuki
Akihiko Eguchi
Kazuhiko Naito
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