インテグリン拮抗剤としてのパラ-アミノ安息香酸

Title:

インテグリン拮抗剤としてのパラ-アミノ安息香酸

Document Type and Number:

Japanese Patent JP2005508941

Kind Code:

A

Abstract:

The present invention relates to compounds of the general formula (I), their preparation and use as pharmaceutical compositions asintegrin antagonists, especially as alpha4beta and/or alpha4beta7 ?and/or alpha9beta1 intergrin antagonists and in particular for the production of pharmaceutical compositions suitable for the inhibition or the prevention of cell adhesion and cell-adhesion mediated disorders. Examples are the treatment and the prophylaxis of atherosclerosis, asthma, chronic obstructive pulmonary disease (COPD), allergies, diabetes, inflammatory bowel disease, multiple sclerosis, myocardial ischemia, rheumatoid arthritis, transplant rejection and other inflammatory, autoimmune and immune disorders.

Inventors:

Thomas Lehmann
Marx Albers
Thomas Lele
Gerhard Mueller
Gerhard Hessler
Tajimi Masaomi
Carl Ziegelbauer
Hiromi Okigami
Kevin bacon
Haruki Hasegawa

Application Number:

JP2003533921A

Publication Date:

April 07, 2005

Filing Date:

September 20, 2002

Export Citation:

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Assignee:

Bayer HealthCare AG

International Classes:

A61K31/192; A61K31/196; A61K31/197; A61K31/216; A61K31/27; A61K31/341; A61K31/40; A61K31/4015; A61K31/402; A61K31/405; A61K31/417; A61K31/4172; A61K31/423; A61K31/425; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4465; A61K31/495; A61K31/4965; A61K31/5377; A61P1/04; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P19/02; A61P25/00; A61P29/00; A61P37/02; A61P37/06; A61P37/08; C07C275/42; C07D207/09; C07D207/14; C07D207/27; C07D209/20; C07D211/26; C07D211/56; C07D213/38; C07D213/40; C07D213/56; C07D233/54; C07D233/64; C07D241/04; C07D263/58; C07D277/20; C07D295/12; C07D277/30; C07D295/13; C07D307/14; C07D413/12; C07D207/26; (IPC1-7): C07C275/42; A61K31/196; A61K31/197; A61K31/216; A61K31/27; A61K31/341; A61K31/40; A61K31/4015; A61K31/402; A61K31/405; A61K31/417; A61K31/4172; A61K31/423; A61K31/425; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4465; A61K31/495; A61K31/4965; A61K31/5377; A61P1/04; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P19/02; A61P25/00; A61P29/00; A61P37/02; A61P37/06; A61P37/08; C07D207/09; C07D207/14; C07D207/27; C07D209/20; C07D211/26; C07D211/56; C07D213/38; C07D213/56; C07D233/64; C07D241/04; C07D263/58; C07D277/20; C07D277/30; C07D295/12; C07D307/14; C07D413/12

Foreign References:

WO2001000206A1

2001-01-04

Attorney, Agent or Firm:

Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Yasuo Shibata

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