PARA-CHLORO-N-(3-MORPHOLINOPROPYL)BENZAMIDE, ITS HYDROCHLORIDE, PROCESS FOR PREPARATION OF THE SAME AND MEDICINAL PREPARATION BASED ON HYDROCHLORIDE OF COMPOUND HAVING ANTIDEPRESSION EFFECT AND MENTAL STIMULATING EFFECT

Title:

Document Type and Number:

Japanese Patent JPS6450874

Kind Code:

A

Abstract:

NEW MATERIAL: The para-chloro-N-(3-morpholinopropyl)benzamide expressed by formula I (X is HCl or absence) and its hydrochloride.

USE: A low-toxicity medicine exhibiting an antidepression effect and mental stimulating effect.

PROCESS: The compd. of the formula is obtd. by bringing N-(3-aminopropyl) morpholine and parachlorobenzoylchloride into reaction in a polar org. solvent (more preferably ethanol, isopropanol, acetone, 1.2-dichloroethane, chloroform, methylene chloride or acetonitrile) which prohibits the formation of by-products, then isolating the product. The para-chloro-N-(3-morpholinopropyl)benzamide is obtd. if the para-chloro-N-(3-morpholinopropyl)benzamide hydrochloride is brought into reaction with an alkali in an aq. medium.

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Inventors:

ARUTOURU BIKUTOROBICHI BARUDOM
MARINA MIHAIROFUNA KOZUROFUSUK
FURADEIMIRU AREKUSEEBICHI ZAGO
KURARA IBANOFUNA ROPATEINA
TATOYANA AREKUSANDOROFUNA BORO
FURADEIMIRU BARENTEINOBICHI KU
TATOYANA FURADEIMIROFUNA SOKOR
DOMITORI YURIEBICHI RUSAKOFU
RUYUBOFU NIKORAEFUNA NEROBUKOB
NIKORAI ANDOREBICHI AFUDOUROFU
BORISU IBANOBICHI RUYUBIMOFU
BORISU MIHAIROBICHI PUYATEIN
ORUGA BASHIRIEFUNA SHIERUBAKOB

Application Number:

JP20361887A

Publication Date:

February 27, 1989

Filing Date:

August 18, 1987

Export Citation:

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Assignee:

NII FARMAKOLOGII A MEDICINSKIJ

International Classes:

C07D295/12; A61K31/535; A61K31/5375; A61P25/24; A61P25/26; (IPC1-7): A61K31/535; C07D295/12

Attorney, Agent or Firm:

Aoki Akira

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