Title:
腫瘍を標的指向化する薬物を封入した粒子
Document Type and Number:
Japanese Patent JP4927535
Kind Code:
B2
Abstract:
A composition for delivering a tumor therapeutic agent to a patient includes a fast-release formulation of a tumor apoptosis inducing agent, a slow-release formulation of a tumor therapeutic agent, and a pharmaceutically acceptable carrier. An apoptosis-inducing agent in a pharmaceutically acceptable carrier may be administered before or concomitantly therewith. Nanoparticles or microparticles (e.g., cross-linked gelatin) of the therapeutic agent (e.g., paclitaxel) also may be used. The nanoparticles or microparticles may be coated with a bioadhesive coating. Microspheres that agglomerate to block the entrance of the lymphatic ducts of the bladder to retard clearance of the microparticles through the lymphatic system also may be employed. This invention also uses drug-loaded gelatin and poly(lactide-co-glycolide) (PLGA) nanoparticles and microparticles to target drug delivery to tumors in the peritoneal cavity, bladder tissues, and kidneys. Fig. 1 (left) shows multiple tumors disseminated through the peritoneal cavity of a mouse implanted with intraperitoneal human Hs766T pancreatic xenograft tumors under room light and (right) under UV light.
Inventors:
AU, Jessie, L., -S.
Wintees M Jurome
Wintees M Jurome
Application Number:
JP2006509638A
Publication Date:
May 09, 2012
Filing Date:
April 02, 2004
Export Citation:
Assignee:
AU, Jessie, L., -S.
International Classes:
A61K31/337; A61K9/00; A61K9/16; A61K9/50; A61K9/51; A61K9/52; A61K31/335; A61K31/704; A61K45/06; A61K47/02; A61K47/26; A61K47/32; A61K47/34; A61K47/36; A61P35/00; C07D305/00; C07H15/252; A61K
Foreign References:
| WO2000061141A2 | 2000-10-19 |
Attorney, Agent or Firm:
Yoichi Oshima