Title:
PEG-MODIFIED RECONSTRUCTED HEMOGLOBIN HAVING SOD ACTIVITY AND METHOD FOR PRODUCING THE SAME
Document Type and Number:
Japanese Patent JP2005027512
Kind Code:
A
Abstract:
To provide a PEG (polyethylene glycol)-modified reconstructed Hb (hemoglobin) having an SOD (superoxide dismutase) activity provided with biocompatibility, retentivity in blood and the SOD activity and to provide a method for producing the same.
The feature is as follows. A metal complex of a cationized porphyrin (or a cationized metal porphyrin complex) is synthesized. Hb is reconstructed by using the synthesized metal complex. The resultant reconstructed hemoglobin is then modified with the polyethylene glycol to carry out the production.
Inventors:
YUASA MAKOTO
MIDORIKAWA UICHI
YAMAGUCHI ARITOMO
KAWAKAMI HIROYOSHI
NAGAOKA SHOJI
ABE MASAHIKO
TAKEBAYASHI TAKASHI
MIDORIKAWA UICHI
YAMAGUCHI ARITOMO
KAWAKAMI HIROYOSHI
NAGAOKA SHOJI
ABE MASAHIKO
TAKEBAYASHI TAKASHI
Application Number:
JP2003193140A
Publication Date:
February 03, 2005
Filing Date:
July 07, 2003
Export Citation:
Assignee:
YUASA MAKOTO
International Classes:
C12N9/02; A61K38/16; A61K47/48; A61P39/06; C07K14/805; (IPC1-7): C12N9/02; A61P39/06; C07K14/805
Attorney, Agent or Firm:
Shunsuke Nakao
Takashi Ito
Naoko Okura
Fumari Tamari
Takeyuki Suzuki
Shiro Isoda
Takashi Ito
Naoko Okura
Fumari Tamari
Takeyuki Suzuki
Shiro Isoda
Previous Patent: METHOD FOR CULTURING P. YUCATENSIS(MURR.)IMAZ.
Next Patent: METHOD FOR EXPRESSING HOMOIOTHERMISM
Next Patent: METHOD FOR EXPRESSING HOMOIOTHERMISM