Title:
PEPTIDE-DRUG CONJUGATE
Document Type and Number:
Japanese Patent JP2019189623
Kind Code:
A
Abstract:
To provide tumor-specific peptide-drug conjugates and a pharmaceutical composition containing the conjugates.SOLUTION: The present invention provides a peptide-drug conjugate, selected from the group consisting of Ala-Ala-Asn-PABC-mitomycin, Nα-succinamic acid-Ala-Ala-Asn-PABC-mitomycin, Nα-acetamide-Ala-Ala-Asn-PABC-mitomycin, Nα-butyramide-Ala-Ala-Asn-PABC-mitomycin, Nα-hexanamide-Ala-Ala-Asn-PABC-mitomycin, Ala-Ala-Asn-PABC-doxorubicin, Nα-succinamic acid-Ala-Ala-Asn-PABC-doxorubicin, Nα-acetamide-Ala-Ala-Asn-PABC-doxorubicin, Nα-butyramide Ala-Ala-Asn-PABC-doxorubicin .SELECTED DRAWING: None
Inventors:
CHU SHAOSONG
Application Number:
JP2019107602A
Publication Date:
October 31, 2019
Filing Date:
June 10, 2019
Export Citation:
Assignee:
JIARAY PHARMACEUTICALS INC
International Classes:
A61K47/54; A61K31/16; A61K31/18; A61K31/337; A61K31/352; A61K31/407; A61K31/4745; A61K31/475; A61K31/519; A61K31/704; A61K31/7048; A61K31/7064; A61K31/7068; A61K38/12; A61K47/55; A61K47/60; A61K47/64; A61K47/65; A61P35/00; A61P43/00; C07K5/083; C07K5/10; C07K7/02; C07K14/00
Attorney, Agent or Firm:
Norihito Yamao
Yasushi Ochiai
Yasushi Ochiai