NEW MATERIAL: Compounds (salts) represented by the formula I (wherein: X is H, a 1-5C alkoxycarbonyl group or the like; V is Cys, a 2-6C ω- thioalkylcarbonyl group or the like; A is Phe or the like; A1 is Gly or the like; A2 is Gly or the like; B is Arg or the like; C is Ile or the like; D is Asp or the like; E is Gln or the like; F is Ser or the like; G is Gly or the like; Z is a group represented by the formula II (wherein: H is Asn or the like; I is Ser or the like; J is Phe or the like; K is Arg or the like; L is Gly or the like; and M is Arg-OH or the like))
USE: Pharmaceuticals such as diuretic agent, vaso-relaxant, immunomodulator or glaucoma therapeutic agent.
PREPARATION: The preparation of such a compound represented by the formula I, for example, comprises: successively linking amino acids, each of which has an α-amino group protected from a C-terminal amino acid, to a resin according to the amino acid sequence of the corresponding peptide; thereafter, repeating the operation of removing the amino-protecting groups to form a peptide resin; releasing the peptide from the peptide resin; and thereafter, oxidizing the released peptide to form a disulfide linkage and accordingly, to prepare the objective peptide compound.
YOHEN KUNORE
BUORUFUGANGU KEENIHI
MAKUSU ROPOTSUTO
