Title:
アシネトバクター・バウマンニ（Ａｃｉｎｅｔｏｂａｃｔｅｒ ｂａｕｍａｎｎｉｉ）に対するペプチド大環状分子
Document Type and Number:
Japanese Patent JP7460541
Kind Code:
B2
Abstract:
The present invention provides compounds of formula (I)wherein X1, X2, R1 to R6 and A are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by bacteria.
Inventors:
Breicher, Konrad
Chen, Daniela
Di Giorgio, Patrick
Wu, Taishan
Jenny, Christian
Mattei, Patrizio
Schmidz, Petra
Stol, Theodor
Chen, Daniela
Di Giorgio, Patrick
Wu, Taishan
Jenny, Christian
Mattei, Patrizio
Schmidz, Petra
Stol, Theodor
Application Number:
JP2020558432A
Publication Date:
April 02, 2024
Filing Date:
April 23, 2019
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07K7/54; A61K38/12; A61P31/04
Foreign References:
| WO2017072062A1 |
Other References:
Wei Wang et al.,Design and synthesis of novel x2-constrained phenylalanine, naphthylalanine, and tryptophan analogues and their use in biologically active melanotropin peptides,Tetrahedron,2002年12月31日,58(36),7365-7374
Hiroki Azuma et al.,Preparation of Horner-Wadsworth-Emmons reagent: Methyl 2-Benzyloxycarbonylamino-2-(Dimethoxy-Phosphinyl)Acetate,Organic Synthesis,2011年01月14日,2011(88),152-161
Wei Wang et al.,Practical, asymmetric synthesis of aromatic-substituted bulky and hydrophobic tryptophan and phenylalanine derivatives,Tetrahedron,2002年12月31日,58(15),3101-3110
Hiroki Azuma et al.,Preparation of Horner-Wadsworth-Emmons reagent: Methyl 2-Benzyloxycarbonylamino-2-(Dimethoxy-Phosphinyl)Acetate,Organic Synthesis,2011年01月14日,2011(88),152-161
Wei Wang et al.,Practical, asymmetric synthesis of aromatic-substituted bulky and hydrophobic tryptophan and phenylalanine derivatives,Tetrahedron,2002年12月31日,58(15),3101-3110
Attorney, Agent or Firm:
Osamu Yamamoto
Toru Miyamae
Junichi Matsuo
Toru Miyamae
Junichi Matsuo