PEPTIDYL DERIVATIVE AS INHIBITOR OF INTERLEUKIN-1BETA-CONVERTING ENZYME

Title:

PEPTIDYL DERIVATIVE AS INHIBITOR OF INTERLEUKIN-1BETA-CONVERTING ENZYME

Document Type and Number:

Japanese Patent JPH05271274

Kind Code:

A

Abstract:

PURPOSE: To provide a novel compd. which has the activity to inhibit interleukin-1β-converting enzyme and is useful for the inflammation treatment, etc., of the lung, central nervous system, kidney, etc.

CONSTITUTION: The compd. of the formula I [Y is formula II (R2 is (-CN); R1 is a (substd.) alkyl, aryl, etc.; AA1 to AA3 are a single bond, selected from various kinds of amino acids). For example, N-(N-acetyltyrosinyl-valinyl- lysinyl)-3-amino-3-cyanopropionic acid. The compd. of the formula I is obtd. by hydrolyzing a compd. of formula IV obtd. by using, for example, a compd. of formula III as a starting material.

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Inventors:

Kevin Tay Cheupman
Marcolm Matsukos

Application Number:

JP33306292A

Publication Date:

October 19, 1993

Filing Date:

December 14, 1992

Export Citation:

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Assignee:

Merck End-Campany Inc.

International Classes:

A61K38/55; A61P29/00; C07C255/29; C07K5/02; C07K5/06; C07K5/08; C07K5/087; C07K5/10; A61K38/00; (IPC1-7): C07K5/10; A61K37/64; C07K5/08

Attorney, Agent or Firm:

Yoshio Kawaguchi (2 outside)

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