Title:
PEPTIDYLAMINO DIOL
Document Type and Number:
Japanese Patent JPS62234052
Kind Code:
A
Abstract:
A renin inhibiting compound of the formula: wherein A is a substituent; W is C=O or CHOH; U is CH2 or NR2, provided that when W is CHOH then U is CH2; R1 is loweralkyl, cycloalkylmethyl, benzyl, 4-methoxybenzyl, halobenzyl, (1-naphthyl)methyl, (2-naphthyl)methyl, (4-imidazoyl)methyl, alpha , alpha -dimethylbenzyl, 1-benzyloxyethyl, phenethyl, phenoxy, thiophenoxy or anilino; R2 is hydrogen or loweralkyl; R3 is loweralkyl, [(alkoxy)alkoxy]alkyl, (thioalkoxy)alkyl, lowerakenyl, benzyl or heterocyclic ring substituted methyl; R4 is loweralkyl, cycloalkylmethyl or benzyl; R5 is vinyl, formyl, hydroxymethyl or hydrogen; R7 is hydrogen or loweralkyl; R8 and R9 are independently selected from OH and NH2; and R6 is hydrogen, loweralkyl, vinyl or arylalkyl; provided that when R5 and R7 are both hydrogen and R8 and R9 are OH, the carbon bearing R5 is of the "R" configuration and the carbon bearing R6 is of the "S" configuration; or pharmaceutically acceptable salts or esters thereof. Also disclosed are renin inhibiting compositions, a method of treating hypertension, methods of making the renin inhibiting compounds and intermediates useful in making the renin inhibiting compounds.
Inventors:
JIEI RICHIYAADO RARII
YAKOBU JIYON PURATONAA
DEIRU JIYON KENPU
YAKOBU JIYON PURATONAA
DEIRU JIYON KENPU
Application Number:
JP628087A
Publication Date:
October 14, 1987
Filing Date:
January 16, 1987
Export Citation:
Assignee:
ABBOTT LAB
International Classes:
A61K31/16; A61K31/165; A61K31/18; A61K31/215; A61K31/22; A61K31/255; A61K31/33; A61K31/535; A61K31/5375; A61K38/00; A61P9/12; A61P43/00; C07C67/00; C07C213/00; C07C215/20; C07C215/26; C07C215/28; C07C217/44; C07C231/00; C07C231/12; C07C235/06; C07C235/08; C07C235/10; C07C235/74; C07C237/08; C07C215/10; C07C237/10; C07C237/22; C07C239/00; C07C269/00; C07C271/16; C07C273/10; C07C301/00; C07C303/30; C07C303/40; C07C309/63; C07C311/00; C07C313/00; C07C323/60; C07D233/54; C07D233/64; C07D241/24; C07D295/18; C07D521/00; C07K1/113; C07K5/02; C07K5/06; C07K5/065; C07K5/083; C07K5/097; C07K14/81; C12N9/99; (IPC1-7): A61K31/16; A61K31/165; A61K31/18; A61K31/215; A61K31/255; A61K31/33; A61K31/535; A61K37/02; C07C91/02; C07C93/02; C07C102/00; C07C103/38; C07C103/44; C07C103/50; C07C103/76; C07C125/06; C07C143/68; C07C143/72; C07C149/14; C07D233/64; C07D241/24; C07D295/18; C07D521/00; C07K5/06; C12N9/99
Domestic Patent References:
| JPS6133152A | 1986-02-17 |
Attorney, Agent or Firm:
Yoshio Kawaguchi (3 outside)