PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF

Title:

PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF

Document Type and Number:

Japanese Patent JP2014065719

Kind Code:

A

Abstract:

To provide compounds useful for treatment, prevention, amelioration, delay or reduction of severity and/or incidence of side effects associated with opioid administration.

Compounds of the formula I-a or I-b are useful as peripheral μ opioid receptor antagonists.

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Inventors:

ALFRED A AVEY
APPAVU CHANDRASEKAREN
DOSHAN HAROLD D
PEREZ JULIO
YAKOV ROTSHTEYN

Application Number:

JP2013240006A

Publication Date:

April 17, 2014

Filing Date:

November 20, 2013

Export Citation:

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Assignee:

PROGENICS PHARM INC
WYETH LLC

International Classes:

C07D489/08; A61K31/485; A61P1/04; A61P1/08; A61P1/10; A61P7/10; A61P17/00; A61P17/04; A61P25/04; A61P43/00

Foreign References:

WO2006127899A2

2006-11-30

Other References:

JPN6013022985; Ｋｏｊｉ　Ｕｗａｉ　ｅｔ　ａｌ．: Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．１２, 2004, ｐ．４１７-４２１
JPN6013022988; Ｓ．　Ｌａｚａｒ　ｅｔ　ａｌ．: Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　ＣｈｅｍｉｓｔｒｙＶｏｌ．２９，　Ｎｏ．１, 1994, ｐ．４５-５３

Attorney, Agent or Firm:

Takuji Yamada
Aoyama Aoi
Michiko Matsutani
Satoshi Hashimoto

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