PESTICIDAL POLYCYCLIC COMPOUND, INTERMEDIATE, DRUG CONTAINING SAME AND USE AS MEDICINE

Title:

PESTICIDAL POLYCYCLIC COMPOUND, INTERMEDIATE, DRUG CONTAINING SAME AND USE AS MEDICINE

Document Type and Number:

Japanese Patent JPS59225149

Kind Code:

A

Abstract:

Compounds of the formula (I)or monomethyl or monoethyl ethers thereof, the compounds of formula (I) including their ethers containing no more than 30 carbon atoms in total, or esters or salts thereof; wherein Aris perylene,fluoranthene, chrysene, pyrene or triphenylene, optionally substituted by one or two substituents, or when Ar is anthracene or phenanthrene optionally substituted by one, two or three substituents; said substituents containing not more than four carbon atoms in total when taken together being the same or different and are selected from halogen; cyano; C_1-4alkyl or C_1-4alkoxy, each optionally substituted by hydroxy or C_1-2alkoxy; halogen substituted C_l-₂alkyl or C₁-₂alkoxy; halogen substituted Ci-2 alkyl or C_1-2alkoxy; a group S(O)nR² wherein n is an integer 0,1 or 2 and R² is C_1-2alkyl optionally substituted by hydroxy or C₁- ₂alkoxy; or Ar is optionally substituted by a group NR³R₄ containing not more than 5 carbon atoms wherein R³ and R' are the same or different and each is a Ci-3alkyl group or NR³R⁴ forms a five-or six-membered heterocyclic ring optionally containing one or two additional heteroatoms; R' contains not more than eight carbon atoms and is a groupor wherein m is 0 or 1;R⁵ is hydrogen or methyl;R⁶ and R' are the same or different and each is hydrogen or C1-3alkyl optionally substituted by hydroxy;R⁸ and R⁹ are the same or different and each is hydrogen or Ci-3alkyl;-C-C- is a five-or six-membered saturated carbocyclic ring; R¹⁰ is hydrogen, methyl or hydroxymethyl; R", R¹² and R¹³ are the same or different and each is hydrogen or methyl; R¹⁴ is hydrogen, methyl, hydroxy, or hydroxymethyl; and provided that when Ar is 6-chrysenyl, 3- or 7-fluoranthenyl, 2-triphenylenyl, or 1- or 9-anthracenyl optionally substituted by one or two substituents as hereinbefore defined; other than optionally substituted butyl or butoxy R⁶ is C_1-3alkyl optionally substituted by hydroxy; R⁷ is hydrogen, C1-3alkyl or hydroxymethyl; R'to R¹² and R" are as hereinbefore defined; R¹³ is hydrogen; and m is 0; R⁵ is methyl, are disclosed as having biocidal and, in particular, antitumour activity. Methods for preparing the compounds, formulations containing them and their use in medicine are also described.

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Inventors:

KENESU UORUTAA BEA

Application Number:

JP9965584A

Publication Date:

December 18, 1984

Filing Date:

May 16, 1984

Export Citation:

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Assignee:

WELLCOME FOUND

International Classes:

A61K31/045; A61K31/135; A61K31/255; A61K31/275; A61K31/415; A61K31/42; A61K31/535; A61K31/5375; C07D295/08; A61P31/00; A61P35/00; B01J27/135; C07B61/00; C07C29/147; C07C33/46; C07C63/44; C07C63/70; C07C66/02; C07C67/00; C07C69/76; C07C205/15; C07C213/00; C07C213/02; C07C215/06; C07C215/08; C07C215/10; C07C215/20; C07C215/28; C07C215/38; C07C215/42; C07C215/44; C07C217/48; C07C217/58; C07C253/00; C07C255/56; C07C255/58; C07C313/00; C07C315/04; C07C317/32; C07C317/36; C07C319/20; C07C323/32; C07C323/36; C07C323/38; C07D213/02; C07D233/61; C07D263/52; C07D263/64; C07D295/10; C07D295/12; C07D295/135; C07D309/12; C07D317/32; C07D319/06; C07D498/04; C07D521/00; C07J63/00; C07D263/62; (IPC1-7): C07C91/02; A61K31/135; A61K31/275; C07C147/00; C07C149/32; C07D498/04

Foreign References:

US2865925A

1958-12-23

Attorney, Agent or Firm:

Akaoka Michio

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