Title:
結腸デリバリー用の医薬投与形態
Document Type and Number:
Japanese Patent JP3902228
Kind Code:
B2
Abstract:
The present invention relates to a pharmaceutical composition in a unit dosage form for peroral administration in a human or lower animal, having a gastrointestinal tract comprising a small intestine and a colon with a lumen therethrough having an inlet to the colon from the small intestine, comprising: a. a safe and effective amount of a therapeutically active agent incorporated into or coated on the surface of a dosage form selected from the group consisting of a spherical substrate, an elliptical substrate, a hard capsule, or a compressed tablet, with a maximum diameter of about 3 mm to about 10 mm; and b. an enteric polymer coating material; wherein the dosage form has a smooth surface free from edges or sharp curves; the elliptical substrate and the hard capsule have a ratio of the long to short diameters of no greater than about 1.5; the therapeutically active agent is released at a point near the inlet to, or within the colon; the enteric polymer coating material begins to dissolve in an aqueous media at a pH between about to about 6.3; and the enteric polymer coating material has a coating thickness of at least about 250 mu m.
Inventors:
Gary Robert, Kelm
Manling, garry lee
Manling, garry lee
Application Number:
JP53502596A
Publication Date:
April 04, 2007
Filing Date:
May 16, 1996
Export Citation:
Assignee:
Taisho Pharmaceutical Co., Ltd.
International Classes:
A61K9/00; A61K9/30; A61K9/58; A61K9/32; A61K9/36; A61K9/48; A61K9/50; A61K9/52; A61K9/62; A61K31/196; A61K31/4402; A61K31/573; A61K38/23; A61K47/30; A61K47/32; A61K47/38; A61P1/10; A61P29/00; A61P37/06
Domestic Patent References:
| JP5178747A | ||||
| JP5506217A | ||||
| JP4501411A | ||||
| JP222222A | ||||
| JP5610311A | ||||
| JP647047B2 |
Attorney, Agent or Firm:
Michiteru Soga
Michiharu Soga
Yutaka Ikeya
Hidetoshi Furukawa
Suzuki Kenchi
Kajinami order
Taizo Shiraishi
Michiko Daigo
Michiharu Soga
Yutaka Ikeya
Hidetoshi Furukawa
Suzuki Kenchi
Kajinami order
Taizo Shiraishi
Michiko Daigo