Title:
PHARMACEUTICAL COMBINATION OF ANGIOTENSIN RECEPTOR ANTAGONIST AND NEP INHIBITOR
Document Type and Number:
Japanese Patent JP2011252013
Kind Code:
A
Abstract:
To provide a novel medicine used in the treatment of hypertensive vascular disease.
This invention relates to dual-acting compounds and combinations of novel angiotensin receptor blockers and neutral endopeptidase inhibitors. More specifically, this invention relates to a dual-acting compound, such as a supermolecular complex, comprising: (a) an angiotensin receptor antagonist; (b) a neutral endopeptidase inhibitor (NEPi); and optionally (c) a pharmaceutically acceptable cation. A specific combination, linked pro-drug or a compound of an angiotensin receptor antagonist and a NEPi are used in the treatment of hypertension.
Inventors:
FENG LILI
GODTFREDSEN SVEN ERIK
KARPINSKI PIOTR
SUTTON PAUL ALLEN
PRASHAD MAHAVIR
GIRGIS MICHAEL J
HU BIN
LIU YUGANG
BLACKLOCK THOMAS J
GODTFREDSEN SVEN ERIK
KARPINSKI PIOTR
SUTTON PAUL ALLEN
PRASHAD MAHAVIR
GIRGIS MICHAEL J
HU BIN
LIU YUGANG
BLACKLOCK THOMAS J
Application Number:
JP2011177091A
Publication Date:
December 15, 2011
Filing Date:
August 12, 2011
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
C07D257/04; A61K31/216; A61K31/41; A61K31/4178; A61K31/4184; A61K31/4422; A61K31/549; A61K31/55; A61K45/06; A61P3/10; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P17/00; A61P25/06; A61P25/28; A61P27/02; A61P27/06; A61P43/00; C07D223/16; C07D235/20; C07D403/10; C07D409/06
Domestic Patent References:
| JP2003533440A | 2003-11-11 | |||
| JPH08245385A | 1996-09-24 | |||
| JPH05310664A | 1993-11-22 | |||
| JP2005514441A | 2005-05-19 | |||
| JP2005533023A | 2005-11-04 | |||
| JP4824754B2 | 2011-11-30 |
Foreign References:
| EP0498361A2 | 1992-08-12 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Mami Hino
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Mami Hino
Yasuhito Suzuki