PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDER

Title:

PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDER

Document Type and Number:

Japanese Patent JP2011137027

Kind Code:

A

Abstract:

To provide a pharmaceutical composition which contains a compound capable of exerting an influence on such a pharmaceutical composition as, especially, acetylcholine level.

The pharmaceutical composition incorporates a pharmaceutically effective amount of at least two components, one of those components being a nicotinic compound capable of interacting with nicotinic cholinergic receptors (for example, a nicotinic agonist, such as E-metanicotine) and one of those components being an acetylcholinesterase inhibitor (for example, tacrine). The pharmaceutical composition is useful for treating CNS (central nervous system) disorders, such as Alzheimer's disease.

Inventors:

BENCHERIF MEROUANE

Application Number:

JP2011038189A

Publication Date:

July 14, 2011

Filing Date:

February 24, 2011

Export Citation:

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Assignee:

TARGACEPT INC

International Classes:

A61K45/06; A61K31/435; A61K31/4375; A61K31/44; A61K31/465; A61K31/473; A61K31/55; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/28

Domestic Patent References:

JPH08325267A	1996-12-10
JPH08505633A	1996-06-18

Foreign References:

WO1998054181A1

1998-12-03

Other References:

JPN6010061005; Ｂｅｎｓｏｎ，　Ｊ．Ａ．　ｅｔ　ａｌ．: Ｊ．Ｅｘｐ．Ｂｉｏｌ．Ｖｏｌ．１７０, 1992, ｐｐ．２０３-２３３
JPN6010061001; Ｌｅｖｙ，　Ｒ．　ｅｔ　ａｌ．: ＢＭＪＶｏｌ．３００, 1990, ｐｐ．１１３１-１１３２
JPN6009039503; Ｄｒｕｇ　Ｄｅｖｅｌｏｐｍｅｎｔ　ＲｅｓｅａｒｃｈＶｏｌ．３８，　Ｎｏ．３-４, 1996, ｐ．１６９-１７６
JPN6009039505; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｐｈａｒｍａｃｏｌｏｇｙ　ａｎｄ　Ｅｘｐｅｒｉｍｅｎｔａｌ　ＴｈｅｒａｐｅｕｔｉｃｓＶｏｌ．２７９，　Ｎｏ．３, 1996, ｐ．１４２２-１４２９

Attorney, Agent or Firm:

Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo

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