Title:
乾癬及び他の皮膚疾患の治療のための製薬組成物
Document Type and Number:
Japanese Patent JP2005513139
Kind Code:
A
Abstract:
The invention relates to a pharmaceutical composition for the treatment of psoriasis and other skin diseases. The inventive composition comprises 17-clobetasol propionate and hydroxy derivative of progesterone having formula (I), wherein: R6 denotes H or methyl; R11 denotes H or hydroxyl and R17 denotes H or hydroxyl, but R11 and R17 cannot be H simultaneously. Preferably, said composition is administered as a lotion with 0.05-0.2 % 17-clobetasol propionate; 0.3-1 % of (I); a solvent selected from among ethanol, isopropanol and mixtures thereof; 40 % cosolvent selected from among propylene glycol, glycerine, sorbitol and mixtures thereof; and 20 % water. In the ideal lotion, the solvent is ethanol and the cosolvents are approximately: 35 % propylene glycol, 5 % glycerine and 20% water. The invention affords the following advantages: longer interval between recurrences and fewer local secondary effects. Moreover, the inventive composition can be used for the treatment of psoriasis.
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Inventors:
Pidal Fernandez, Rosalia
Tomasi Siano, Giuseppe
La Lagnaga Rascano, Lydia
Tomasi Siano, Giuseppe
La Lagnaga Rascano, Lydia
Application Number:
JP2003554707A
Publication Date:
May 12, 2005
Filing Date:
December 11, 2002
Export Citation:
Assignee:
Rita Pearl Laboratorios S.A.
International Classes:
A61K8/63; A61K9/00; A61K31/57; A61K31/573; A61K47/10; A61K47/26; A61P17/00; A61P17/06; A61P29/00; A61P37/08; A61Q19/00; C07J7/00; (IPC1-7): A61K31/57; A61K47/10; A61K47/26; A61P17/00; A61P29/00; A61P37/08
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori