Title:
PHARMACEUTICAL COMPOSITION
Document Type and Number:
Japanese Patent JPH03106827
Kind Code:
A
Abstract:
PURPOSE: To obtain a pharmaceutical composition having improved absorption through a mucomembranous tissue, giving a sufficient hypolevel and useful for oral and intestinum rectum administration by containing an antibacterial compound and 2- or 3-components-based absorbefacient system. CONSTITUTION: This pharmaceutical composition is composed of (A) an antibacterial compound, especially β-lactam antibiotics (e.g. ceftriaxone), (B) an absorbefacient system composed of B1 : an ester of polyoxyethylene (PEG) with a 6-16C glyceride, e.g. PEG-8 caprylate/caprylate glyceride ester and B2 : an 8-18C carboxylic acid voluntarily containing its salt, e.g. caprylic acid, and voluntarily (C) a pharmaceutical composition having a pharmaceutically inert liquid. A containing amount of each component is suitably A=50-250ng and B=100-500mg in a case of oral administration and A=100-1,500mg and B=100-500mg in a case of intestinum rectum administration, about respective dose unit.
Inventors:
MARIA OKUSANA BACHINSUKII
ARUBAATO DABIDOBITSUCHI
MAACHIN HAWAADO INFUERUDO
NABUNITO SHIYAA
JIYOERU UNOUSUKII
ARUBAATO DABIDOBITSUCHI
MAACHIN HAWAADO INFUERUDO
NABUNITO SHIYAA
JIYOERU UNOUSUKII
Application Number:
JP23980790A
Publication Date:
May 07, 1991
Filing Date:
September 10, 1990
Export Citation:
Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K9/02; A61K31/397; A61K31/40; A61K31/43; A61K31/535; A61K31/545; A61K45/06; A61K47/12; A61K47/14; A61K47/34; C07D499/21; A61P31/04; C07D205/085; C07D403/04; C07D405/04; C07D499/861; C07D499/897; (IPC1-7): A61K31/40; A61K31/535; A61K31/545; A61K45/06; A61K47/12; A61K47/34; C07D205/085; C07D403/04; C07D405/04; C07D499/02
Attorney, Agent or Firm:
Heiyoshi Odashima