Title:
医薬化合物
Document Type and Number:
Japanese Patent JP2010521446
Kind Code:
A
Abstract:
The invention provides a composition comprising ( S ) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of ( R ) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the ( S ) and ( R ) enantiomers in which the ( S ) enantiomer predominates. Also provided are processes for the preparation of the ( S ) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.
Inventors:
Steven, John, Woodhead
David, Charles, Reese
Martin, Frederickson
Kaila, Meriom, Grim Show
David, Charles, Reese
Martin, Frederickson
Kaila, Meriom, Grim Show
Application Number:
JP2009553222A
Publication Date:
June 24, 2010
Filing Date:
March 14, 2008
Export Citation:
Assignee:
ASTEX THERAPEUTICS LIMITED
The Institute of Cancer Research: Royal Cancer Hospital
The Institute of Cancer Research: Royal Cancer Hospital
International Classes:
C07D231/12; A61K31/415; A61P35/00; A61P43/00; C07C213/02; C07C215/32; C07C247/10
Foreign References:
| WO2005061463A1 | 2005-07-07 | |||
| WO2006136837A2 | 2006-12-28 | |||
| WO2006136821A1 | 2006-12-28 |
Attorney, Agent or Firm:
Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Hiroyuki Fujii
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Hiroyuki Fujii