Title:
医薬化合物
Document Type and Number:
Japanese Patent JP5073177
Kind Code:
B2
Abstract:
Tricyclic pyrazole derivatives of the following formula (I) having affinity for the cannabinoidergic CB1 and/or CB2 receptors: wherein: A represents a group selected from one of the following: (CH2)t-, -(CH2)-S(O)z-, or -S(O)z-(CH2)-, B is a heteroaryl, optionally substituted; R is a group selected from the following: alkyl, aryl, arylalkyl or arylalkenyl, not substituted or having from one to four substituents, equal to or different from each other; R' is a group selected from the following: an ether group of formula -(CH2)-O-(CH2)v-R", a ketonic group of formula -C(O)-Z', wherein Z' is as defined below; a substituent having an hydroxyl function of formula -CH(OH)-Z'; an amide substituent of formula -C(O)-NH-T'.
Inventors:
Paolo, Lazzari
Stephania, Riu
Gerald, Emme, Pinna
Gabriele, Mulinedou
Stephania, Riu
Gerald, Emme, Pinna
Gabriele, Mulinedou
Application Number:
JP2005150888A
Publication Date:
November 14, 2012
Filing Date:
May 24, 2005
Export Citation:
Assignee:
NEUROSCIENZE PHARMANESS S.C.A R.L.
International Classes:
C07D495/04; A61K31/4162; A61K31/454; A61K51/00; A61P1/08; A61P3/04; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P13/00; A61P13/12; A61P19/02; A61P19/10; A61P21/00; A61P25/00; A61P25/06; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P25/36; A61P27/02; A61P29/00; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07D231/54; A61K31/55
Domestic Patent References:
| JP9502449A | ||||
| JP2003513099A | ||||
| JP2003513077A | ||||
| JP7309841A |
Foreign References:
| WO2003070236A1 | ||||
| WO2003070706A1 | ||||
| US5547975 |
Other References:
MUSSINU,J. et al,Tricyclic Pyrazoles. Part 1: Synthesis and Biological Evaluation of Novel 1,4-Dihydroindeno[1,2-c]pyrazol-based Ligands for CB1and CB2 Cannabinoid Receptors,Bioorganic & Medicinal Chemistry,2003年,Vol.11, No.2,pp.251-263
Attorney, Agent or Firm:
Hirohito Katsunuma
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito
Yukitaka Nakamura
Noritaka Yokota
Takeyasu Ito