Title:
医薬化合物
Document Type and Number:
Japanese Patent JP5329395
Kind Code:
B2
Abstract:
Fused pyrimidines of formula (I): wherein A, n, R1, R2, and R3 have any of the values defined herein and the pharmaceutically acceptable salts thereof have activity as inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behavior associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.
Inventors:
Chakkorie, Irina, S.
Forks, Adrian, Jay.
Goldsmith, Paul
Hancox, Timothy, Sea.
Shuttle Worth, Stephan, Jay.
Forks, Adrian, Jay.
Goldsmith, Paul
Hancox, Timothy, Sea.
Shuttle Worth, Stephan, Jay.
Application Number:
JP2009508465A
Publication Date:
October 30, 2013
Filing Date:
May 04, 2007
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D495/04; A61K9/20; A61K31/519; A61K45/00; A61P3/00; A61P5/00; A61P9/00; A61P25/00; A61P29/00; A61P31/12; A61P35/00; A61P35/02; A61P37/06; A61P43/00; A61P1/16; A61P3/10; A61P7/02; A61P9/10; A61P11/00; A61P17/06; A61P19/00; A61P25/16; A61P25/28; A61P31/00; A61P37/08; C07B61/00
Domestic Patent References:
| JP2005120102A |
Foreign References:
| WO1999040091A1 | ||||
| WO2005014558A1 |
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Yasuhito Suzuki