PURPOSE: A pharmaceutical of doxorubicin salt, obtained by incorporating a dissolution assistant, e.g. a lower alkanoic acid or amino acid, in the doxorubicin salt which is ananthracycline based antitumor agent, and capable of dissolving even in a salt solution in a short time.
CONSTITUTION: A least one of a lower alkanoic acid, lower alkanoic diacid, hydroxy lower alkanoic acid, amino acid, and urea-related substances as a dissolution assistant is incorporated in a doxorubicin salt expressed by the formula to give the titled pharmaceutical having improved solubility. A 2W4C hydroxy lower alkanoic acid, phenylalanine, serine, and urea etc. are preferred for the dissolution assistant, and the amount thereof to be used is preferably 1/10W3 times (W/W) of that of the doxorubicin salt. The dissolution time is remarkably reduced as compared with the case in the absence of the dissolution assistant.
SUZUKI YOUKO
HAYAKAWA EIJI
MORIYAMA YOSHIO
KONDOU AKIRA
| JPS5569515A | 1980-05-26 | |||
| JPS5668619A | 1981-06-09 | |||
| JPS558967A | 1980-01-22 |
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