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Title:
PHARMACEUTICAL OF DOXORUBICIN SALT
Document Type and Number:
Japanese Patent JPS6092212
Kind Code:
A
Abstract:

PURPOSE: A pharmaceutical of doxorubicin salt, obtained by incorporating a dissolution assistant, e.g. a lower alkanoic acid or amino acid, in the doxorubicin salt which is ananthracycline based antitumor agent, and capable of dissolving even in a salt solution in a short time.

CONSTITUTION: A least one of a lower alkanoic acid, lower alkanoic diacid, hydroxy lower alkanoic acid, amino acid, and urea-related substances as a dissolution assistant is incorporated in a doxorubicin salt expressed by the formula to give the titled pharmaceutical having improved solubility. A 2W4C hydroxy lower alkanoic acid, phenylalanine, serine, and urea etc. are preferred for the dissolution assistant, and the amount thereof to be used is preferably 1/10W3 times (W/W) of that of the doxorubicin salt. The dissolution time is remarkably reduced as compared with the case in the absence of the dissolution assistant.


Inventors:
FURUYA KUNITOSHI
SUZUKI YOUKO
HAYAKAWA EIJI
MORIYAMA YOSHIO
KONDOU AKIRA
Application Number:
JP20037983A
Publication Date:
May 23, 1985
Filing Date:
October 26, 1983
Export Citation:
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Assignee:
KYOWA HAKKO KOGYO KK
International Classes:
A61K9/08; A61K31/70; (IPC1-7): A61K9/08; A61K31/71
Domestic Patent References:
JPS5569515A1980-05-26
JPS5668619A1981-06-09
JPS558967A1980-01-22